OBJECTIVE: To investigate the effect of Bushen Jianpi formula (BSJP) therapy on survival of the patients with moderate and advanced hepatocellular carcinoma (HCC).METHODS: This was a five-year retrospective study,enrolling 209 adult patients with moderate and advanced HCC patients.Log-rank test,Cox regression analysis and Kaplan-Meier analysis was applied to analyze the data.RESULTS: The outcome of single-factor Kaplan-Meier analysis and Log-rank test showed that stage of Barcelona-clinic liver cancer (BCLC),Iocoregional therapy and BSJP therapy were three factors that dominantly influenced the survival of moderate and advanced HCC patients (P ＜ 0.05).In Cox multiple-factor regression analysis,lower BCLC staging (RR =2.016;P =0.000),Iocoregional therapy (RR =0.611;P =0.011) and BSJP therapy (RR =0.684;P =0.044) were the independent protective factors affecting survival of patients,and BSJP exerted a more significant effect on patients at BCLC-C stage (RR =0.513;P =0.002).CONCLUSION: BSJP therapy and Iocoregional therapy both contributed to prolonged survival for moderate and advanced HCC patients.