Krüpple样转录因子8(KLF8)是KLFs家族中一名年轻的成员,能结合细胞中DNA的GC box或CACCC元件,调控富含GC启动子的基因表达,参与调节细胞周期[1]。研究表明[2],KLF8在人体多种恶性肿瘤中过表达,与肿瘤的发生、发展密切相关。新近研究发现[3-4],KLF8与多种血管生成因子的表达关系密切,故研究KLF8参与肿瘤新生血管生成的作用 Krüpple-like transcription factor 8 (KLF8), a young member of the KLFs family, regulates the cell cycle by regulating GC-rich gene expression in combination with GC box or CACCC elements of DNA in cells [1]. Studies have shown that [2], KLF8 overexpression in a variety of human malignancies, and tumor occurrence and development are closely related. Recent studies found that [3-4], KLF8 expression of a variety of angiogenic factors are closely related, so KLF8 study the role of tumor angiogenesis