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作者收集了英格兰、威尔士1975～1981年间在皇家学院和Dulwish等15所医院的125例镰状细胞病孕妇(病人组)的资料,并与1977～1979年间上述两所医院产前检验的同种族的717例未患镰状细胞病的孕妇(对照组)进行比较。资料均经统计学处理。两组的年龄、婚姻状况和社会经济状况无差异。病人组既往1年以上不育率(6.4%)、早期自然流产率(18.4%)、死产率(16.4%)均明显高于对照组(对应数字分别为2.5%、12.4%和2.2%)(P<0.01)。病人组镰状细胞病危象发生率产前为38%,产后为21.6%。3种不同类型本病(即Hbss-SC和S
The authors collected data on 125 sickle cell mothers (patients) from 15 hospitals in Royal College and Dulwish between 1975 and 1981 in England and Wales and compared them to the same ethnicity in the prenatal tests of the two hospitals from 1977 to 1979 Of 717 pregnant women without sickle cell disease (control group) were compared. Data are processed by statistics. There was no difference in age, marital status and socioeconomic status between the two groups. In the past one year or more, the infertility rate (6.4%), early spontaneous abortion rate (18.4%) and stillbirth rate (16.4%) in the patient group were significantly higher than those in the control group (corresponding to 2.5%, 12.4% and 2.2% respectively) (P <0.01). The incidence of sickle cell disease in the patient group was 38% prenatal and 21.6% postpartum. Three different types of the disease (ie Hbss-SC and S