本文通过牵张信号如何入胞→激活胞内信号通路情况→信号分子致胞内特定基因表达及蛋白合成顺序 ,简要综述机械牵张致心肌细胞肥大分子机制。1　转导牵张信号跨膜入胞的可能分子机制1 .1 　 牵张敏感通道 (SACs)最早报道SACs存在于鸡胚骨骼肌细胞膜 ,后来在新生鼠心肌细胞及成 This article briefly reviewed the molecular mechanism of mechanical stretch induced hypertrophy in cardiomyocytes by stretching the signal into the cell → activating the intracellular signal pathways → the intracellular specific gene expression induced by the signaling molecule and the order of the protein synthesis. 1 transduction stretch signal transmembrane entry possible molecular mechanism 1.1 Stretching Sensitive Pathways (SACs) SACs first reported in the chicken embryo skeletal muscle cell membrane, and later in neonatal rat cardiomyocytes and into