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本文研究了静脉注射氢化考的松(135mg)对柯兴病患者血N-POMC水平的影响,并和阿狄森病及先天性肾上腺皮质增生症进行比较。结果证明,柯兴病患者(包括未治组、肾上腺次全切组及纳尔逊综合征组)静注氢考后血N-POMC的抑制率明显低于阿狄森病组及先天性肾上腺皮质增生症组(P<0.001),而柯兴病三组间无明显差别。以上结果说明,在柯兴病患者,AGTH/N-POMC分泌对糖皮质激素负反馈调节的反应是迟钝的,这种迟钝反应与血皮质醇水平的高低无直接关系,却反映了柯兴病患者垂体ACTH分泌的相对自主性。
This article investigates the effect of intravenous cortisol (135 mg) on blood levels of N-POMC in patients with cortisone and compared with Addison’s disease and congenital adrenal hyperplasia. The results showed that the inhibitory rate of N-POMC in Cushing’s disease patients (including those in the control group, sub-adrenalectomy group and Nelson syndrome group) was significantly lower than that in Addison disease group and congenital adrenal hyperplasia Disease group (P <0.001), while there was no significant difference between the three groups. The above results show that in patients with Cochin disease, AGTH / N-POMC secretion of glucocorticoid negative feedback regulation of the response is slow, this slow response and the level of serum cortisol has no direct relationship, but reflects the Cushing’s disease The relative autonomy of pituitary ACTH secretion in patients.