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心喘灵(XC-1)ip 26 mg/kg可使小鼠利多卡因中毒时的死亡率由对照组的14/20下降至2/20(p<0.05);iv时,其拮抗利多卡因毒性的ED_(50)为18.1±0.3mg/kg。iv XC-1 5～10mg/kg并可分别拮抗BaCl_2和CaCl_2诱发的大鼠心律失常;ip2.5mg/kg亦能明显降低氯仿诱发的小鼠室颤率(p<0.01)。在整体和离体实验中发现,XC-1可明显减慢心率,且能拮抗异丙肾上腺素加快心率的作用。实验结果提示,XC-1可能是通过阻滞β受体,降低心肌耗氧而对心脏产生一定的保护作用.
XC-1 ip 26 mg/kg reduced the mortality of mice with lidocaine poisoning from 14/20 in the control group to 2/20 (p<0.05); when iv, it antagonized lidocaine The ED_(50) for toxicity was 18.1±0.3 mg/kg. Iv XC-1 5 ~ 10mg/kg can antagonize BaCl2 and CaCl2 induced rat arrhythmia; ip2.5mg/kg can also significantly reduce the ventricular fibrillation induced by chloroform in mice (p <0.01). In whole and in vitro experiments, it was found that XC-1 can significantly slow down the heart rate and can antagonize the effect of isoproterenol in accelerating the heart rate. The experimental results suggest that XC-1 may have a protective effect on the heart by blocking β-receptors and reducing myocardial oxygen consumption.