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40例月经正常的健康妇女志愿参与研究。20例(组Ⅰ)为18～25岁,20例(组Ⅱ)为35～40岁。盆腔检查排除盆腔病变后,于每个妇女月经周期的第3、4、5天采集基础血液样品,5～9天每天给与100mg枸橼酸克罗米芬(CC),并于第10天重新采集血液样品。所有样品均测定LH、F5H和E_2;第10天的样品还用以测定CC的E、Z同分异构体(E为雌激素拮抗剂;Z为雌激素促效剂),然后CC为这两种异构体的混合剂给药。
Forty healthy women with normal menstruation volunteered to participate in the study. Twenty patients (group Ⅰ) were 18 to 25 years old and 20 patients (group Ⅱ) were 35 to 40 years old. Pelvic examination After exclusion of pelvic lesions, basal blood samples were taken on days 3, 4 and 5 of each woman’s menstrual cycle, and clomiphene citrate (CC) 100 mg daily for 5 to 9 days and reabsorbed on day 10 Blood samples. LH, F5H, and E_2 were determined for all samples; samples on Day 10 were also used to determine the E, Z isomers of CC (E is an estrogen antagonist; Z is an estrogen agonist) and then CC is A mixture of two isomers is administered.