山西省新绛县制药厂生产的梅花点舌丹,具有百年历史,其配方不同于《中国药典》所载。药理实验结果表明:梅花点舌丹对小鼠S_(180)的抑制率为54.92%,对u_(14)、S_(37)实体瘤抑制率亦在40%左右;预防性给药,剂量在500mg/kg/日时,对S_(180)实体瘤抑制率达58.97%,对u_(14)实体瘤却没有显示出效果;在接种肿瘤后间歇给药的实验中,未发现有抑瘤作用;梅花点舌丹与MMC联合用药,可提高抑瘤率;在毒性实验中,未见明显中毒现象。 The plum blossom menthol produced in Xinyi County, Shanxi Province, has a hundred-year history and its formula is different from that in the Chinese Pharmacopoeia. The results of the pharmacological experiments showed that the inhibitory rate of S. tumefaciens on mice was 54.92%, and that of u_(14) and S_(37) solid tumors was also around 40%. Prophylactic dosing was used at doses of At 500 mg/kg/day, the inhibition rate of S_(180) solid tumors was 58.97%, but it had no effect on solid tumors of u_(14). No anti-tumor effect was found in the experiment of intermittent administration after tumor inoculation. ; Tonghua Dan Tong Dan combined with MMC, can increase the rate of tumor inhibition; toxicity test, no obvious poisoning.