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在中毒性疾病中,急性有机磷中毒(AOPP)是急诊科常见的疾病之一。对 AOPP 的救治原则已被大家所熟知,阿托品等抗胆碱药在抢救 AOPP 中发挥重要作用,在理论上早期,足量,反复给药,快速阿托品化而避免阿托品中毒是抢救成功的关键。但是在临床工作中,达到上述标准并非易事。近年来阿托品中毒的发生率高达40%～60%,死亡率占AOPP 死亡的18.8%,本人通过维普中文全文期刊数据库查阅2000～2005年有关文献近百篇文章结合本人的工作经验,总结在 AOPP 救治中失败及成功的经验并就阿托品的应用及治疗进展,作一文献综述并与大家进行探讨。
Among the toxic diseases, acute organophosphate poisoning (AOPP) is one of the common diseases in the emergency department. AOPP treatment principles have been well known, anticholinergic drugs such as atropine rescue AOPP play an important role in the theory of early, adequate, repeated administration, rapid atropine and avoid atropine poisoning is the key to the success of the rescue. However, in clinical work, to achieve the above criteria is not easy. In recent years, the incidence of atropine poisoning as high as 40% to 60%, the mortality rate accounted for 18.8% of AOPP death, I personally through the VIP Chinese full-text periodical database access 2000 ~ 2005 articles nearly 100 articles combined with my work experience summarized in the AOPP Treatment failure and success of the experience and atropine application and treatment progress, make a literature review and to discuss with you.