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通常认为,人T细胞可以根据其表面的Fc受体的不同而分为两类,具有IgGFc受体者为Tγ细胞,具有IgM Fc受体者为Tμ细胞;并认为Tγ细胞具有抑制和杀伤功能,Tμ细胞具有辅助功能。作者用几种抗人T细胞的单克隆抗体和抗人单核细胞的及抗Ia抗原的单克隆抗体,对Tγ和Tμ细胞作了鉴定。本实验中所用的单克隆抗体具有①OKT_3(与100%人T细胞反应);②OKT_4(与60%的T细胞反应,这群细胞具有辅助功能);③OKT_5(与20%的T细胞反应,这群细胞具有抑制和杀伤功能);④OKM_1(与人单核细胞起反应);⑤OKI_1(与人Ia抗原反应);⑥OKT_6(只与人胸腺细胞反应而与外周成
It is generally considered that human T cells can be classified into two types according to the Fc receptors on their surface, Tγ cells with IgGFc receptor, and Tμ cells with IgM Fc receptor; Tγ cells are considered to have inhibitory and killing functions , Tμ cells have ancillary functions. The authors identified Tγ and Tμ cells using several monoclonal antibodies against human T cells and monoclonal antibodies against human monocytes and anti-Ia antigens. The monoclonal antibodies used in this experiment have ①OKT_3 (which responds to 100% human T cells); ②OKT_4 (which responds to 60% of T cells and has ancillary functions); OKT_5 (which responds to 20% of T cells, Cells inhibit and kill function); ④OKM_1 (reacts with human monocytes); ⑤OKI_1 (reacts with human Ia antigen); ⑥OKT_6 (react only with human thymocytes and peripherally