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目的评价医院抗病原微生物药物应用状况及趋势。方法对2003—2005年第三军医大学新桥医院抗病原微生物药物利用情况进行统计、分析。结果3年间各类抗病原微生物药物总的用药金额、用药频度(DDDs)迅速增长,年平均增长率分别为50.90%和31.76%;用药金额头孢菌素类药物最高,氨基糖苷类药物和抗真菌药物的增长速度最快;口服制剂、注射制剂用量均逐年增加,用药金额和DDDs的年平均增长率分别为24.89%,58.40%和30.87%,34.02%。结论建议合理使用并进一步规范管理抗病原微生物药物,以充分发挥其疗效,减少不良反应,延缓细菌耐药性的发展。
Objective To evaluate the status and trends of hospital anti-pathogenic microorganisms. Methods The statistics and analysis of anti-pathogenic microorganism utilization in Xinqiao Hospital of the Third Military Medical University from 2003 to 2005 were analyzed. Results The total amount of medication and the frequency of DDDs of various antimicrobial agents increased rapidly with an average annual growth rate of 50.90% and 31.76% respectively over the three years. The amount of cephalosporins used was the highest, while that of aminoglycosides Anti-fungal drugs grew fastest; the dosage of oral preparations and injectable preparations increased year by year, and the average annual growth rates of medication amount and DDDs were 24.89%, 58.40% and 30.87% and 34.02% respectively. Conclusion It is suggested that the rational use and further standardized management of anti-pathogenic microbiological drugs in order to give full play to its efficacy, reduce adverse reactions, delay the development of bacterial resistance.