钙通道阻滞剂(calcium channel blo-ckers,CCB)在临床应用日益广泛。通过阻断钙离子进入细胞内,而影响心、脑、肾和血管平滑肌的功能。在冠心病、心绞痛、脑血管疾病及高血压等疾病具有良好效果。近年的研究发现,CCB能阻止肾血管平滑肌、肾小球系膜及肾小管上皮细胞的钙内流,影响肾血流量和肾小球滤过率,增加水 Calcium channel blockers (calcium channel blo-ckers, CCB) in the clinical application of increasingly widespread. By blocking calcium ions into the cell, which affect the heart, brain, kidney and vascular smooth muscle function. In coronary heart disease, angina, cerebrovascular disease and hypertension and other diseases with good results. In recent years, the study found that CCB can prevent renal vascular smooth muscle, mesangial and tubular epithelial cells of calcium influx, affecting renal blood flow and glomerular filtration rate, increase water