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近年来分子内1,3-偶极环加成反应引起了较大的注意,它被用来合成某些杂环、多环以及结构复杂的天然产物,为了解决中间体问题,我们摸索了某些芳环醛肟(N-4-戊烯基)氮酮Nitrone的合成方法.通常,醛肟与活泼的卤代烃作用得到N-烷基化产物和O-烷基肟.某些碘代烃对光敏感,不很稳定,产率较低,我们采用溴代烃,方法简便,产率较高.表1给出某些芳环醛肟的烷基化产物,从中看出,Z型肟(1,4,7,12,17,20)主要生成N-烷基化产物,N/O比值为4.73—6.80;E型肟(10,15)主要生成O-烷基肟(11,16),N/O比值为0.14—0.15。
In recent years, intramolecular 1,3-dipolar cycloaddition reaction has attracted more attention. It is used to synthesize certain heterocyclic, polycyclic and complex natural products. In order to solve the intermediate problem, we explored a The synthesis of some aromatic ring oxydimethyl (N-4-pentenyl) Azone Nitrone. Generally, the aldoxime acts with an active halogenated hydrocarbon to give the N-alkylated product and the O-alkyloxime. Hydrocarbons are light sensitive, not very stable, and have low yields, and we use brominated hydrocarbons in a simple, high yield manner. Table 1 gives alkylated products of certain aromatic ring aldoximes, The oxime (1,4,7,12,17,20) mainly produced N-alkylated products with a N / O ratio of 4.73-6.80. E-type oxime (10,15) mainly produced O-alkyloxime (11, 16) with a N / O ratio of 0.14-0.15.