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目的：研究盐酸小檗碱与环孢素Ａ长期联合应用增加肾移植受者环孢素Ａ血浓度的作用。方法：５２名服用环孢素Ａ＋盐酸小檗碱患者为试验组，５２名单服环孢素Ａ患者为对照组，以环孢素Ａ全血浓度及肝、肾功能生化检测指标作为临床评价指标。结果：合用盐酸小檗碱患者环孢素Ａ全血浓度与合用前比较增幅达７５％，与对照组比较有显著性提高（Ｐ＜０．００１）。盐酸小檗碱与环孢素Ａ合用对肝、肾功能无明显影响。结论：盐酸小檗碱能明显升高肾移植受者环孢素Ａ血浓度。在升高环孢素Ａ血浓度的同时，盐酸小檗碱并不增加环孢素Ａ的毒性反应。盐酸小檗碱与环孢素Ａ合用可减少环孢素Ａ用药量，节省环孢素Ａ费用。
Objective: To study the long-term combined effect of berberine hydrochloride and cyclosporin A on the blood concentration of cyclosporine A in renal transplant recipients. Methods: 52 patients taking cyclosporin A + berberine hydrochloride as test group, 52 patients taking cyclosporine A as control group. The whole blood concentration of ciclosporin A and biochemical indexes of liver and kidney were used as clinical evaluation indexes . Results: The concentration of cyclosporine A in patients with combination of berberine hydrochloride increased 75% compared with that before administration, which was significantly higher than that of the control group (P <0.001). Berberine hydrochloride combined with cyclosporine A had no significant effect on liver and kidney function. Conclusion: Berberine hydrochloride can significantly increase the concentration of cyclosporine A in renal transplant recipients. Berberine hydrochloride does not increase the toxic effects of cyclosporin A while increasing the blood concentration of cyclosporine A. Berberine hydrochloride combined with cyclosporine A can reduce the dose of cyclosporine A, save the cost of cyclosporine.