组胺H_2受体拮抗剂甲氰咪胍自1975年合成以来,已广泛应用于消化性溃疡、上消化道出血、Zollinger-Ellison综合征或其他高胃酸状态、胰腺功能不全吸收不良等胃肠疾病。又发现对胰腺炎、原发性甲状旁腺机能亢进、皮肤疾患、肿瘤、妇女多毛症等胃肠外疾病有效。随着此药在临床上的广泛使用,与其他药物共同使用的情况也逐渐增多,已发现该药能与某些药物相互影响,这方面报道较多,现综合如下。 Since its synthesis in 1975, the histamine H 2 receptor antagonist, cimetidine, has been widely used in gastrointestinal diseases such as peptic ulcer, upper gastrointestinal bleeding, Zollinger-Ellison syndrome or other conditions with high gastric acidosis and poor pancreatic insufficiency . Also found that pancreatitis, primary hyperparathyroidism, skin disorders, cancer, hirsutism in women and other parenteral diseases effective. With the widespread use of this medicine in the clinic, the use of it in combination with other drugs has also gradually increased. It has been found that this drug can interact with certain drugs and has been reported in many aspects.