氟尿嘧啶和紫杉类药物是乳腺癌治疗的两类基本药物 ,近年来它们的前体或同类药物的研究与应用日渐增多。本文报道在人乳腺癌模型中 capecitabine或其中间代谢产物去氧氟尿苷联合紫杉特尔在给药时间不同的各种方案之疗效 ,并对其机制作了初步探讨。给 MX- 1人乳腺癌移植小鼠连续 Fluorouracil and taxanes are two types of essential drugs for the treatment of breast cancer, and their precursors or similar drugs have been increasingly studied and applied in recent years. This paper reports the efficacy of capecitabine or its intermediate metabolite doxifluridine plus docetaxel in various regimens for different time points in the human breast cancer model, and provides a preliminary discussion of its mechanism. MX-1 human breast cancer transplanted mice were consecutive