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目的 :研究胆汁在不同类型的细菌感染时血浆内毒素含量的变化。方法 :胆囊切除术中取胆汁作细菌培养和涂片染色镜检。革兰氏阴性菌感染者 ( 40例 )、革兰氏阳性菌感染者 ( 40例 )和菌检阴性者 (对照组 4 0例 )共 1 2 0例 ,均在胆囊切除术前后测定血浆内毒素水平。结果 :术前革兰氏阴性菌感染组血浆内毒素水平明显高于革兰氏阳性菌感染组和对照组 (P <0 .0 1 ) ,革兰氏阳性菌感染组与对照组之间无明显差异 (P >0 .0 5) ;术后革兰氏阴性菌感染组血浆内毒素水平很快下降与术前比较有极显著差异 (P <0 .0 1 )。结论 :血浆内毒素定量测定 ,可作为判断胆汁感染轻重程度和观察治疗效果的指标。
Objective: To study the changes of plasma endotoxin levels in different types of bacterial infections. Methods: Gallbladder choled for bacterial culture and smear microscopy. Gram-negative bacteria (40 cases), Gram-positive bacteria (40 cases) and negative bacteria (control group 40 cases) were 120 cases, were measured before and after cholecystectomy plasma Endotoxin levels. Results: The level of plasma endotoxin in Gram-negative bacteria infection group before operation was significantly higher than that in Gram-positive bacteria infection group and control group (P <0.01). There was no difference between Gram-positive bacteria infection group and control group (P> 0.05). The plasma endotoxin level in patients with Gram-negative bacterial infection after operation was significantly lower than that before operation (P <0.01). Conclusion: The quantitative determination of plasma endotoxin can be used as an indicator to judge the severity of biliary infection and to observe the therapeutic effect.