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类固醇避孕剂对乳腺癌的发生率和预后的影响仍未能肯定。在许多种动物中,雌激素是致癌的。大量雌激素可使人的乳腺肿瘤消退,但小剂量可加剧生长率。在1978年,估计有5,400万妇女服用口服避孕药,几组研究表明曾服这些药物的妇女乳腺癌发生率并无增加,但是口服避孕药是否影响已确诊的乳腺癌预后仍有争论。大多数外科医生劝告最近诊断乳腺癌的患者不要用类固醇避孕药。Spencer等报告44例在乳癌诊断前一年服用口服避孕药的患者与从未服用口服避孕药的对照组患者作了比较,他们没有发现口服这些药物引起病变加剧的证据。因为乳腺癌临床前期可延长许多年。作者对曾经用类固醇避孕药的患者作了进一步研究并报告其结果。
The effect of steroid contraceptives on the incidence and prognosis of breast cancer remains uncertain. Estrogen is carcinogenic in many species of animals. Large amounts of estrogen can make the human breast tumor subsided, but the small dose can exacerbate the growth rate. In 1978, an estimated 54 million women took oral contraceptives. Several groups of studies showed no increase in the incidence of breast cancer among women who had taken these drugs, but whether oral contraceptives affect the prognosis of a confirmed breast cancer remains controversial. Most surgeons advise patients who have recently been diagnosed with breast cancer not to use steroid contraceptives. Spencer et al reported 44 patients who took oral contraceptives a year prior to breast cancer diagnosis compared with control subjects who had never taken oral contraceptives and found no evidence of their exacerbation being taken orally. Because breast cancer preclinical can be extended for many years. The authors further studied the patients who had used steroid contraceptives and reported the results.