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目的：探讨原发性肺癌ＬＮ和ＦＮ的表达与转移及预后的关系。方法：采用免疫组化ＬＳＡＢ法检测１７９例肺癌标本中ＬＮ和ＦＮ的表达。结果：中、高分化的肺鳞癌的ＬＮ的表达强度明显不同于低分化者（ｔ＊＝３．０７，２．６７，Ｐ均＜０．０１），ＬＮ的表达强度在有无淋巴结转移的两组鳞癌间，差异具有显著性意义（χ２＝１１．１３，Ｐ＜０．０５），ＬＮ和ＦＮ的表达强度在鳞癌５年以上生存组明显不同于半年内死亡组（ｔ△＝２．８５，２．４９，Ｐ△＜０．０１，＜０．０５），ＦＮ表达强度在３组不同生存期的肺腺癌间，差异具有显著性意义（Ｈｃ＝７．５３，Ｐ＜０．０５）。结论：ＬＮ和ＦＮ的表达可作为评估肺癌淋巴结转移及预后的有价值的指标。
Objective: To investigate the relationship between the expression, metastasis and prognosis of LN and FN in primary lung cancer. Methods: The expression of LN and FN in 179 specimens of lung cancer was detected by immunohistochemical LSAB method. Results: The intensity of LN expression in moderately and well differentiated lung squamous cell carcinoma was significantly different from that in poorly differentiated individuals (t*=3.07, 2.67, P<0.01). The intensity of LN expression was in the presence or absence of lymph node metastasis. Between the two groups of squamous cell carcinomas, the difference was significant (χ2=11.13, P<0.05), and the expression intensity of LN and FN in the squamous cell carcinoma over 5 years survival group was significantly different from the death within 6 months (t △ = 2.85, 2.49, P △ <0.01, <0.05), FN expression intensity in three groups of lung adenocarcinomas with different survival periods, the difference was significant (Hc = 7.53, P <0.05). Conclusion: The expression of LN and FN can be used as a valuable index to evaluate the lymph node metastasis and prognosis of lung cancer.