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为探讨急性缺血缺氧对胎儿血清IGF Ⅰ、 Ⅱ水平的影响和IGFs在胎儿发育中的作用 ,对 2 1只SD孕鼠被随机分为对照组 9只 ,实验组 1 2只。钳夹实验组孕鼠双侧子宫动、静脉 2 0分钟建立胎鼠缺血缺氧模型 ,对照组仅行开腹和关腹术。比较两组胎鼠血清IGFs、血糖水平及生长参数和器官重量。结果显示 ,实验组血清IGF Ⅰ、 Ⅱ及血糖浓度分别为 1 1 7 92± 2 6 58ng ml,2 33 1 9± 33 35ng ml及 41 6 7±5 6 1mg dl,明显低于对照组 (分别为 2 34 43± 70 6 5ng ml,397 74± 2 3 6 9ng ml及 6 6 4± 4 95mg dl,P均 <0 0 0 1 ) ,其生长参数和器官重量亦明显低于对照组 (P均 <0 0 0 1 )。因此 ,宫内短期的急性缺血缺氧即可致胎儿宫内发育迟缓 (IUGR) ;IGFs水平的降低可能是IUGR发生中的重要因素
To investigate the effect of acute hypoxia and hypoxia on fetal serum IGF Ⅰ and Ⅱ levels and the role of IGFs in fetal development, 21 SD pregnant rats were randomly divided into control group (n = 12) and experimental group (n = 12). The rats in the experimental group were exposed to bilateral uterine motion and venous for 20 minutes to establish hypoxic-ischemic model in the experimental group, while the control group received laparotomy and laparotomy only. The serum IGFs, blood glucose levels, growth parameters and organ weights of the two groups were compared. The results showed that the levels of serum IGF Ⅰ, Ⅱ and blood glucose in the experimental group were respectively 1 1 7 92 ± 2 6 58ng ml, 2 33 1 9 ± 33 35ng ml and 41 6 7 ± 5 6 1 mg dl, which were significantly lower than those in the control group (P <0.05), and the growth parameters and organ weights were also significantly lower than those of the control group (P All <0 0 0 1). Therefore, intrauterine short-term acute ischemia and hypoxia can cause intrauterine growth retardation (IUGR); reduced levels of IGFs may be an important factor in the occurrence of IUGR