CD2 8是协同 TCR诱导 T细胞产生高水平 IL - 2 ,促进 T细胞生存及防止 T细胞凋亡的主要协同刺激分子 ,但并非所有 T细胞均表达 CD2 8,提示 T细胞活化尚有其它协同刺激途径的存在。最近研究表明 ,其它一些协同刺激分子 ,如 4 - 1BB、OX4 0、ICOS、L FA- 1等在不同的 T细胞亚群和 T细胞活化的不同阶段 ,呈现不同的表达和介导不同的生物学功能 CD2 8 is a major costimulatory molecule that cooperates with TCR in inducing T cells to produce high levels of IL - 2, promoting T cell survival and preventing T cell apoptosis. However, not all T cells express CD28, suggesting that there are other synergistic stimuli for T cell activation Pathways exist. Recent studies have shown that other costimulatory molecules, such as 4 - 1BB, OX4 0, ICOS, L FA-1 and so on, show different expression and mediate different biological processes at different stages of T cell subsets and T cell activation Learn function