枸椽酸氯芪酚胺(下称氯芪酚胺)虽是一种可促进促性腺激素分泌的排卵诱导剂,但也可用于治疗原发性男性不育症,其用药量通常为25mg/天。本文报道以小剂量(5mg/天)长期治疗时血中激素浓度的改变、治疗结果及适应证。对象及方法:对象为精子数量在4000万/ml以下及精子活动率在60％以下,但无精路运输障碍、睾丸未降及精索静脉曲张等基础疾病的原发性男性不育者62例,其中重度精子缺乏(1～19×10~6/ml)31例,中度缺乏(20～39×10~6/ml)15例,轻度缺乏(40～59×10~6/ml)6例,精子无力症(60以上×10~6/ml)10例。平均年龄33.7(27～43)岁。不育时间平均4.6年。氯芪酚胺用量为5ml/天,连用12周以上。疗效 Although it is an ovulation inducer that can promote the secretion of gonadotropin, citraldehyde citrate (hereinafter referred to as “clindamycin amine”) can also be used to treat primary male infertility. The dosage is usually 25mg / day. This article reports a small dose (5mg / day) long-term treatment of blood hormone levels, treatment and indications. PARTICIPANTS AND METHODS: Primary male infertility with sperm count below 40 million / ml and sperm motility rate below 60%, but without essential transport disorder, testicular descent and varicocele Among them, there were 31 cases of severe sperm deficiency (1 ~ 19 × 10 ~ 6 / ml), moderate deficiency (20 ~ 39 × 10 ~ 6 / ml) and mild deficiency (40 ~ 59 × 10 ~ 6 / ml) ) In 6 cases, sperm weakness (60 above × 10 ~ 6 / ml) in 10 cases. The average age of 33.7 (27 ~ 43) years old. The average time of infertility 4.6 years. Chlorhexidine dose of 5ml / day, once every 12 weeks. Efficacy