多发性骨髓瘤(简称MM)是骨髓内浆细胞异常增生的恶性肿瘤。临床特点常有骨质破坏肾脏功能不正常,血沉增快,贫血、血小板减少等。同时常伴有血清免疫球蛋白(Ig)单克隆增殖或本周氏蛋白尿。本病多发生在40岁以上的老年人。在MM中有少数病例血清和小便中测不到增加的单克隆Ig及本周氏蛋白,此组MM被称为非分泌型MM,也叫不分泌型MM、非定型MM、非产生型MM及无M成分MM等。非分泌型MM约占全部MM的1%。我 Multiple myeloma (referred to as MM) is an abnormal proliferation of plasma cells in bone marrow malignancy. Clinical features often have bone destruction of renal dysfunction, ESR, anemia, thrombocytopenia and so on. At the same time often accompanied by serum immunoglobulin (Ig) monoclonal proliferation or the week of proteinuria. The disease occurs in the elderly over the age of 40. In a small number of cases of MM serum and urine can not detect increased monoclonal Ig and this week’s protein, this group MM is called non-secretory MM, also known as non-secretory MM, non-stereotyped MM, non-producing MM And no M components such as MM. Non-secreting MM accounts for about 1% of all MM. I