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目的了解新生儿脐带感染的病原菌及其药敏谱以指导临床治疗。方法从感染分泌物中分离细菌，系统鉴定。用纸片法进行药敏试验，对氨苄青霉素用试管法进行定量药敏试验。结果从９例新生儿中分离出９株细菌：４株肺炎克雷伯氏菌，２株大肠埃氏菌，２株其它革兰氏阴性杆菌，１株金黄色葡萄球菌。纸片法显示它们均对氨苄青霉素抗药；试管法显示５株菌的ＭＩＣ为４０～７０μｇ／ｍｌ，另４株为６００～５０００μｇ／ｍｌ。结论对于ＭＩＣ为４０～７０μｇ／ｍｌ的菌，青霉素加氨苄青霉素（１５０ｍｇ／ｋｇ）可以有效，而对ＭＩＣ为６００～５０００μｇ／ｍｌ的菌上述治疗方案难于奏效，因而应及时分离细菌测其药敏以指导治疗。
Objective To understand the pathogens of neonatal umbilical cord infection and its susceptibility spectrum to guide the clinical treatment. Methods Isolation of bacteria from infected secretions, systematic identification. Susceptibility test with the paper method, ampicillin tube with quantitative test for susceptibility testing. Results Nine strains of bacteria were isolated from nine neonates: four strains of Klebsiella pneumoniae, two strains of Escherichia coli, two strains of other Gram-negative bacilli and one strain of Staphylococcus aureus. They were all resistant to ampicillin by the disk method. The in vitro test showed that the MIC of the five strains was 40-70μg / ml and the other four strains were 600-5000μg / ml. Conclusions Penicillin plus ampicillin (150mg / kg) can be effective for those with MIC of 40 ~ 70μg / ml, while it is hard to treat the bacteria with MIC of 600 ~ 5000μg / ml. Therefore, the bacteria should be tested for their sensitivity To guide the treatment.