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α2 -巨球蛋白可能与淀粉样 β蛋白沉积有关。有报道认为 α2 -巨球蛋白基因 (A2 M)外显子 1 8剪切受体缺失与 Alzheimer’s病 (AD)发生的危险性相关。为寻求脑淀粉样血管病 (CAA)基因危险因素 ,本文探讨了 A2 M多态性缺失与 CAA的关系。对 1 78名日本籍病人 (年龄 62～ 1 0 4岁
α2-macroglobulin may be related to amyloid β protein deposition. It has been reported that the deletion of exon 18 excision receptor of α2-macroglobulin gene (A2 M) is associated with the risk of developing Alzheimer’s disease (AD). In order to find out the risk factors of cerebral amyloid angiopathy (CAA) gene, this paper explored the relationship between A2 M polymorphism deletion and CAA. A total of 1 78 Japanese patients (62 to 104 years of age)