儿童骨髓增殖性疾病常有C组染色体异常,而伴有21-三体细胞系的骨髓增殖性疾病以往尚未见报道。作者报告一例7周岁女孩,因全身多发性瘀斑入院。体检:发育正常,苍白病容,全身皮肤和口腔粘膜可见瘀点瘀斑,肝脾于肋下7厘米处触及,腋下和腹股沟淋巴结均可扪及。皮纹学分析正常。血红蛋白6.4克%,红细胞压积18%,网织红细胞计数17%。白细胞计数6800/立方毫米,其中原粒1%,晚幼粒4%,杆状核47%,多形核31%,淋巴6%,单核9%。血小板计 Chronic myeloproliferative disorders often have chromosomal abnormalities in group C, whereas myeloproliferative disorders associated with the 21-trisomy cell line have not been previously reported. The authors report a seven-year-old girl admitted to hospital with multiple ecchymosis. Physical examination: normal development, pale and sick, the body skin and oral mucosa petechia ecchymosis, liver and spleen hit in the ribs 7 cm Department, armpit and inguinal lymph nodes are palpable. Dermatology analysis of normal. Hemoglobin 6.4%, hematocrit 18%, reticulocyte count 17%. White blood cell count 6800 / cubic millimeter, of which 1% of primordial, late juvenile 4%, 47% of the rod, polymorphonuclear 31%, lymphatic 6%, mononuclear 9%. Platelet count