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目的:探讨十一味益肾降糖片对Ⅲ期糖尿病肾病(DN)大鼠肾损伤的干预作用。方法:采用高糖高脂饮食加链脲佐菌素(STZ)腹腔注射的方法建立Ⅲ期DN大鼠模型,设立空白组(A组)、模型组(B组)、十一味益肾降糖片组(C组)、厄贝沙坦治疗组(D组)。灌胃12周后,检测各组大鼠空腹血糖(FBG)、肾肥大指数(KW/BW)、24 h尿蛋白定量(24-hrUP)、血清胱抑素(CysC)、肾小球硬化指数等指标,取右肾制作病理切片,观察肾脏病理改变。结果:十一味益肾降糖片可改善DN大鼠的一般状况,降低FBG、KW/BW、24-hrUP、CysC等指标;抑制肾小球毛细血管基底膜增厚、系膜基质增生及细胞外基质合成。结论:十一味益肾降糖片可降低Ⅲ期DN大鼠FBG、KW/BW、24-hrUP、CysC等指标;减轻肾脏病理损害,保护肾脏功能。
Objective: To investigate the intervention effect of eleven flavor and kidney tonifying sugar tablet on renal injury of stage Ⅲ diabetic nephropathy (DN) rats. Methods: The model of stage Ⅲ DN rats were established by intraperitoneal injection of streptozotocin (STZ) in high glucose and high fat diet. Group A (blank), model group (group B) Sugar tablets group (C group), irbesartan treatment group (D group). After 12 weeks of gavage, fasting blood glucose (FBG), renal hypertrophy index (KW / BW), 24-hour urine protein content (24-hrUP), serum cystatin (CysC), glomerular sclerosis index And other indicators, take the right kidney pathological section, observe the pathological changes of the kidney. Results: Eleven hypoglycemic hypoglycemic tablets can improve the general condition of DN rats, reduce the indexes of FBG, KW / BW, 24-hrUP and CysC; inhibit glomerular capillary basement membrane thickening, mesangial matrix proliferation and Extracellular matrix synthesis. Conclusion: Eleven taste Yishen Hypoglycemic Tablets can reduce indicators such as FBG, KW / BW, 24-hrUP and CysC in stage III diabetic rats, reduce renal pathological damage and protect renal function.