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目的探讨托拉塞米联合卡托普利治疗慢性舒张性心力衰竭患者的临床疗效。方法选取2014年10月至2015年10月沈阳市经济开发区人民医院心血管内科收治的76例慢性舒张性心力衰竭患者作为研究对象,按随机数字表法分为试验组和对照组,各38例。对照组患者予以托拉塞米,试验组患者在对照组基础上予以卡托普利,比较两组患者临床疗效、脑钠肽(BNP)水平以及6 min步行距离。结果试验组患者治疗的总有效率明显高于对照组,差异有统计学意义(P<0.05);治疗后,试验组患者BNP水平显著低于对照组,6 min步行距离明显高于对照组,差异均有统计学意义(均P<0.05)。结论托拉塞米联合卡托普利治疗慢性舒张性心力衰竭临床疗效显著,能够有效改善心功能。
Objective To investigate the clinical efficacy of torsemide combined with captopril in the treatment of patients with chronic heart failure. Methods From July 2014 to October 2015, 76 patients with chronic diastolic heart failure treated by Department of Cardiology, People’s Hospital of Shenyang Economic Development Zone were enrolled and divided into experimental group and control group according to random number table example. Patients in the control group received torsemide. Patients in the test group were given captopril on the basis of the control group. The clinical efficacy, BNP level and walking distance of 6 min were compared between the two groups. Results The total effective rate of treatment group was significantly higher than that of control group (P <0.05). After treatment, BNP level of test group was significantly lower than that of control group, and the walking distance at 6 min was significantly higher than that of control group The differences were statistically significant (all P <0.05). Conclusion Torasemide combined with captopril in the treatment of chronic diastolic heart failure with significant clinical efficacy, can effectively improve cardiac function.