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Golan(1983)首创用催产素100IU脐静脉注射剥除滞留的胎盘后担心催产素的副作用,将药量减至10IU,但效果很差。为此作者进行了脐静脉注射催产素100IU后母血中药物浓度测定及药效的前瞻性双盲随机试验,以指导临床。先对7例产妇于胎儿娩出后立即脐静脉注射催产素100IU(用生理盐水20ml稀释),从注药前到胎盘娩出连续收集产妇血标本测定催产素浓度,其中值为11(7~19)μU/ml,从注药至胎盘娩出的中值时间为5(1~7)分钟。
Golan (1983) first with oxytocin 100IU umbilical vein stripping placenta stubs worried about the side effects of oxytocin, the dose reduced to 10IU, but the effect is poor. To this end the author conducted oxytocin oxytocin 100IU after maternal serum drug concentration and efficacy of a prospective, double-blind randomized trial to guide the clinical. First of seven cases of mothers in the fetus immediately after delivery of oxytocin oxytocin 100IU (diluted with normal saline 20ml), from injection to the placenta before delivery of maternal blood samples collected oxytocin measured, with a value of 11 (7-19) μU / ml, the median time from injection to the placenta was 5 (1 ~ 7) minutes.