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1984年干部查体时利用醋纤薄膜血红蛋白(Hb)电泳(pH8.6)发现1例慢速异常Hb,其电泳特点:在HbA之后与HbA_2重叠,定量结果远远超出HbA_2(正常含2.5%,本例34%)。血液学检查为正常范围。无贫血、黄疸和肝脾肿大。初步否定了β-地中海贫血(简称地贫)携带者。根据以往河北省普查结果尚未发现此异常类型。现做结构分析摘要如下: 首证者静脉血提纯珠蛋白后肽链裂解经CM-C23柱层析结果表明在BA峰之后
In 1984, cadherin examination revealed a slow abnormal Hb by Hb electrophoresis (pH8.6). The electrophoresis characteristic of HbA2 overlapped with that of HbA2 after HbA, and the quantitative results far exceeded that of HbA2 (2.5% , 34% in this case). Hematology examination for the normal range. No anemia, jaundice and hepatosplenomegaly. Initial negation of β-thalassemia (referred to as thalassemia) carriers. According to the previous census results in Hebei Province has not yet found this type of anomaly. Summary of current structure analysis are as follows: The first certificate of purified blood globin after peptide chain cleavage by CM-C23 column chromatography results show that after BA peak