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细胞质膜受体识别配体的特异性 ,不仅决定于受体的结构 ,而且还与膜上某些调节蛋白的功能有关。最近发现的受体活性修饰蛋白 (RAMP)的I型膜蛋白家系 (RAMP1,RAMP2 ,RAMP3 )分别决定受体呈现不同的表型 ,如RAMP1与降钙素受体样受体 (CRLR)结合表现为降钙素基因相关肽 (CGRP)的功能性受体表型 ,RAMP2或RAMP3与CRLR结合表现为肾上腺髓质素 (ADM)的功能性受体表型。不同的配体CGRP家族成员与不同的受体表型结合 ,通过受体成分蛋白 (RCP)调节参与下游的信号转导 ,发挥不同的生物学效应。RAMPs还参与受体失敏与内化的过程 ,不同RAMPs之间存在相互作用 ,调节配体在病理生理过程中发挥作用。RAMPs对CGRP家族受体表型的调控具有重要的生理和病理意义
The specificity of the cellular plasma membrane receptors to recognize the ligand depends not only on the structure of the receptor, but also on the function of certain regulatory proteins in the membrane. Recently, the type I membrane protein families (RAMP1, RAMP2, RAMP3) of receptor-modified protein (RAMP) were determined to show different phenotypes of receptors, such as the binding of RAMP1 to calcitonin receptor-like receptors (CRLRs) As a functional receptor phenotype of calcitonin gene-related peptide (CGRP), RAMP2 or RAMP3 binds to CRLR as a functional receptor phenotype of adrenomedullin (ADM). Different ligands CGRP family members bind to different receptor phenotypes and participate in the downstream signal transduction through receptor component protein (RCP) regulation to exert different biological effects. RAMPs are also involved in the process of receptor desensitization and internalization. There are interactions between different RAMPs to regulate the ligands in the pathophysiological process. RAMPs on CGRP family receptor phenotype regulation has important physiological and pathological significance