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目的通过耐药性测定为临床化疗方案及控制肺结核流行制定防治对策提供科学依据。方法对308例难治性长期排菌的慢性肺结核及初治菌阳肺结核对照组202例进行耐药性测定。取晨起第一口疾,以2％硫酸作预处理,30分钟后取液化痰没0.1ml接种于改良的罗氏培养基上。结果难治性肺结核耐药的发生率明显高于初治肺结核,不同浓度的INH、RFP、EMB和SM耐药率也有显著性差异(P＜0.01)。结论无论难治性或初治的肺结核,均以耐SM为首位,同时对INH、SM、RFP及EMB的耐药率均较高,。尤具RFP的初始耐药率高达27.2％。
Objective To provide a scientific basis for clinical chemotherapy regimen and prevention and control measures to control the prevalence of tuberculosis through drug resistance determination. Methods A total of 202 chronic tuberculosis patients with chronic refractory chronic mycobacterium tuberculosis and control group of bacillary positive pulmonary tuberculosis were enrolled in this study. Take the first morning stomachache, with 2% sulfuric acid as a pretreatment, after 30 minutes to take liquefied sputum no 0.1ml inoculated on a modified Roche medium. Results The incidence of refractory pulmonary tuberculosis was significantly higher than that of newly diagnosed tuberculosis. There was also a significant difference (P <0.01) among different concentrations of INH, RFP, EMB and SM. Conclusions The resistance to SM is the first in both refractory and untreated tuberculosis patients, and the rates of resistance to INH, SM, RFP and EMB are high at the same time. The initial resistance rate of RFP was as high as 27.2%.