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NF-κB是普遍存在于细胞浆中的一种快反应转录因子,至1986年Sen和Baltimore从小鼠B淋巴细胞中首次发现,并证实其在免疫球蛋白κ轻链基因增强子B序列上有特异性结合位点,能促进κ轻链基因表达[1]以来,对NF-κB的研究从未
NF-κB is a fast-acting transcription factor commonly found in the cytoplasm. It was first reported by Sen and Baltimore in mouse B lymphocytes in 1986 and confirmed to be present on the immunoglobulin κ light chain enhancer B sequence Specific binding sites that promote kappa light chain gene expression [1] have never been studied for NF-κB