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目的探讨血清淀粉样蛋白A(SAA)在缺血性脑血管病中的作用。方法采用ELISA方法,检测动脉粥样硬化性脑梗死急性期病人50例、动脉粥样硬化性脑梗死非急性期病人40例、短暂性脑缺血发作(TIA)病人36例血清SAA与基质金属蛋白酶-9(MMP-9)水平,采用放射免疫比浊法测定C-反应蛋白(CRP)水平,并以50例健康体检者作为对照。结果脑梗死急性期组血清SAA水平高于脑梗死非急性期组、TIA组及对照组(F=49.51,q=15.7~20.0,P<0.01)。脑梗死急性期和TIA病人血清SAA水平与CRP及MMP-9水平呈明显正相关性(r=0.511、0.560,P<0.01)。结论 SAA作为动脉粥样硬化的炎性标志物,参与了动脉粥样硬化性脑梗死的形成,SAA可作为不稳定斑块破裂的早期预警指标。
Objective To investigate the role of serum amyloid A (SAA) in ischemic cerebrovascular disease. Methods ELISA was used to detect 50 cases of acute atherosclerotic cerebral infarction, 40 cases of non-acute atherosclerotic cerebral infarction and 36 cases of transient ischemic attack (TIA) Proteinase-9 (MMP-9) levels, C-reactive protein (CRP) levels by radioimmunoassay method, and 50 healthy subjects as a control. Results Serum SAA levels in the acute stage of cerebral infarction were higher than those in non-acute stage, TIA group and control group (F = 49.51, q = 15.7-20.0, P <0.01). Serum levels of SAA in acute cerebral infarction and TIA patients were positively correlated with CRP and MMP-9 levels (r = 0.511,0.560, P <0.01). Conclusions SAA is an inflammatory marker of atherosclerosis and participates in the formation of atherosclerotic cerebral infarction. SAA can be used as an early warning indicator of unstable plaque rupture.