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目的为探讨β阻滞剂对高血压心率变异性（ＨＲＶ）的影响．方法将４４例高血压患者随机分为治疗组和对照组，治疗组口服美托洛尔５０～１００ｍｇ／ｄ，对照组给予常规剂量的复方降压片治疗，用２４ｈＨｏｌｔｅｒ资料对两组治疗前后ＨＲＶ进行对比分析．结果与对照组比较及治疗组自身对照，治疗组ＨＲＶ明显提高，时域指标中ＳＤＮＮ，ＳＤＡＮＮ，ＳＯＮＮｉｎｄｅ均显著增高（Ｐ＜０．０１），频域指标中ＬＦ成份明显下降，ＨＦ成份明显增加，ＬＦ／ＨＦ也明显下降（Ｐ＜０．０５或＜０．０１）．结论β阻滞剂能有效地改善高血压ＨＲＶ，有助于解释β阻滞剂在高血压患者中的有益作用．
Objective To investigate the effect of β blockers on heart rate variability (HRV) in patients with hypertension. Methods 44 patients with hypertension were randomly divided into treatment group and control group. The treatment group received metoprolol 50 ~ 100mg / d, the control group received conventional dose of compound antihypertensive tablets, 24hHolter data before and after treatment of two groups of HRV For comparative analysis. Results Compared with the control group, the HRV of the treatment group was significantly increased, the SDNN, SDANN and SONNinde in the time domain index were significantly increased (P <0.01), the LF content in the frequency domain index was significantly decreased and the HF content was significantly increased , LF / HF also decreased significantly (P <0.05 or <0.01). Conclusion β blockers can effectively improve the hypertensive HRV, which can help explain the beneficial effects of β blockers in patients with hypertension.