胰岛素依赖型糖尿病(IDDM)患者,在清晨2～7时,维持正常血糖所需的胰岛素量增加,当其量未能相应增加时即引起明显高血糖,称为“黎明”现象。“黎明”现象的发病机理仍不详。有人观察到循环血浆胰高血糖素含量无改变,而氢化可的松、生长激素和儿茶酚胺含量均有增加。此外,在 IDDM 患者中还观察到胰岛素清除率增加。 In patients with insulin-dependent diabetes mellitus (IDDM), the amount of insulin required to maintain normal blood glucose increases between 2 and 7 am, which is called “dawn” when the dose is not increased accordingly. The pathogenesis of the “dawn” phenomenon is still unknown. Someone observed no change in circulating plasma glucagon, while hydrocortisone, growth hormone and catecholamine levels increased. In addition, an increase in insulin clearance was also observed in IDDM patients.