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至今已报告了16例甲亢发生于原发性甲减之后。本文报告的5(女4,男1)例在25～57岁之间发生原发性甲减,均使用L-T_4治疗,而在甲减发生后6个月～34年发生弥漫性甲状腺肿伴甲状腺功能亢进,其中2例有促甲状腺激素(TSH)结合抑制免疫球蛋白,对所有病例均用甲亢平治疗,其中3例因停药而复发。 5例在患甲减期间,均有甲减的临床表现,1例有甲状腺肿大,均无突眼,用L-T_4治疗有效。而在发生甲亢之后,也都有甲亢的临床表现,均有突眼。其中4例甲状腺弥漫性肿大;3例TSH低,对促甲状腺激素释放激素(TRH)有反应,且24小时吸碘率为75～80%;3例测出甲状腺抗体;2例测出抗滤泡
To date, 16 cases of hyperthyroidism have been reported after primary hypothyroidism. This report reported 5 (female 4, male 1) cases of primary hypothyroidism occurred in 25 to 57 years old, are treated with L-T_4, and 6 to 34 years after the occurrence of hypothyroidism, diffuse goiter Accompanied by hyperthyroidism, 2 cases of thyroid-stimulating hormone (TSH) binding inhibition of immunoglobulin, in all cases were treated with hyperthyroidism, of which 3 patients relapsed due to withdrawal. Five patients had hypothyroidism during the clinical manifestations of hypothyroidism, 1 case of goiter, no exophthalmos, with L-T_4 treatment effective. In the event of hyperthyroidism, there are also clinical manifestations of hyperthyroidism, both have exophthalmos. Among them, 4 cases had diffuse thyroid enlargement, 3 cases had low TSH, reacted to thyrotropin-releasing hormone (TRH), and had iodine absorption rate from 75 to 80% in 24 hours. Thyroid antibodies were detected in 3 cases and thyroid antibodies in 2 cases Follicles