内啡肽(β-endorphin)在休克病理生理中开始引人注意,是由于其拮抗药纳洛酮(Naloxone)在逆转休克低血压方面获得明显效果。Holaday 1978年首次报告用清醒未麻醉大鼠内毒素休克模型证明纳洛酮不但逆转低血压,而且有预防内毒素休克的作用。以前有一种看法:认为内毒素可能使机体继发释放内源性的具有心血管作用物质。内啡肽很可能即是这类物质之一。 Endorphin (β-endorphin) is beginning to attract attention in the pathophysiology of shock due to its apparent antagonism of naloxone in reversing shock and hypotension. Holaday first reported in 1978 with awake, unaffected rat endotoxic shock model proved naloxone not only reverse hypotension, but also to prevent the role of endotoxic shock. In the past, there was a belief that endotoxins may cause the body to release endogenous and cardiovascular substances. Endorphins are likely to be one of these substances.