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中枢神经系统曲霉病的死亡率接近100%,治疗效果急需改进。伏立康唑治疗侵袭性曲霉病的有效率和生存率都显著优于两性霉素B,而且,与其他抗真菌药相比,伏立康唑也能更好地穿透血脑屏障,进入中枢神经系统。我们回顾性地评价了81例使用伏立康唑治疗的确诊(n=48)或疑诊(n=33)为中枢
The mortality rate of aspergillosis in the central nervous system is close to 100%, and the treatment effect urgently needs improvement. Voriconazole treatment of aggressive Aspergillosis efficiency and survival rates were significantly better than amphotericin B, and, compared with other antifungal agents, voriconazole can better penetrate the blood-brain barrier into the central nervous system. We retrospectively evaluated 81 diagnosed (n = 48) or suspected (v = 33) voriconazole-treated patients as central