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本文对BALB/c小鼠在接种克拉玛依大沙鼠体内的利什曼原虫后一年内发生的组织病理变化作了系统的观察。结果发现该虫能引起接种部位皮肤的充血、水肿、炎细胞浸润、坏死、脓肿或溃疡形成,继而是纤维母细胞、胶原及网状纤维增生并包围虫群。该虫还能在小鼠的尾、左后肢及两前肢足垫、耳、鼻、肝、脾及淋巴结内的病灶中发现。作者认为该虫不但能引起局部皮肤的严重病变,而且还能不断发生远处转移而产生全身性损害,病灶中的宿主细胞反应,胶原及网状纤维含量等的变化,对促成原虫引起病变的局限化有着重要的作用。
This article systematically observed the histopathological changes of BALB / c mice within one year of Leishmania inoculation of Mus musculus. The results showed that the insects can cause congestion, edema, inflammatory cell infiltration, necrosis, abscess or ulcer formation of the skin at the inoculation site, followed by the proliferation of fibroblasts, collagen and reticular fibrosis surrounding the swarm. The bug is also found in lesions in the caudal, left hindlimbs, and both forelimb foot pads, ears, nose, liver, spleen and lymph nodes. The authors believe that the insects can not only cause severe skin lesions of the local area, but also continue to occur distant metastasis and systemic damage, host cell response in the lesion, changes in collagen and reticular fiber content, contributed to the parasite-induced lesions Limitations play an important role.