Objective To observe the effect of Pinggan Qianyang Recipe(PQR)on inhibiting angiotensinⅡ(AngⅡ)induced proliferation and migration of vascular smooth muscle cells(VSMCs)and changes of DNA methylation.Methods VSMCs were cultured using tissue explant method,and PQR containing serum was prepared.Primarily cultured VSMCs were divided into four Objective To observe the effect of Pinggan Qianyang Recipe (PQR) on inhibiting angiotensin II (Ang II) induced proliferation and migration of vascular smooth muscle cells (VSMCs) and changes of DNA methylation. Methods VSMCs were cultured using tissue explant method, and PQR containing serum was prepared.Primarily cultured VSMCs were divided into four