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目的 探讨嗜碱性粒细胞百分比对慢性肾脏病(CKD)发病的影响.方法 从“山东多中心健康管理纵向观察队列”中抽取年龄20岁以上、至少接受2次健康体检、初次体检未患CKD且无重要指标缺失者建立回顾性队列.将研究对象按基线嗜碱性粒细胞百分比的四分位数分为4组(Q1、Q2、Q3、Q4),应用Cox回归模型分析嗜碱性粒细胞百分比与CKD发生的关联.结果 研究队列包含17173人,男10614人,女6559人.研究期间共随访42204.04人年,新发CKD 737例,发病密度为17.46/1000人年.多元Cox回归模型结果显示,在调整年龄和性别后,以Q1为参照组,Q2、Q3、Q4三组嗜碱性粒细胞百分比的 HR(95%CI)分别为0.990(0.776~1.263)、1.235 (1.011~1.509)、1.352(1.099~1.663);进一步调整体质量指数、高血压、糖尿病、血尿酸、血肌酐、血尿素氮、总胆固醇、低密度脂蛋白胆固醇、甘油三酯后,以Q1组为参照组,Q2、Q3、Q4的HR(95%CI)分别为0.966(0.740~1.262)、1.225(0.985~1.525)、1.355(1.077~1.705).结论 嗜碱性粒细胞百分比升高是CKD发生的独立危险因素.“,”Objective To explore the effect of basophils percentage on the incidence of chronic kidney disease(CKD). Methods A retrospective cohort was conducted using the data from Shandong Multi-center Longitudinal Cohort for Health Management. All subjects ≥20 years old who were free of CKD at baseline and accepted at least two annually physical examinations were selected. The participants were divided into four groups(denoted by Q1,Q2,Q3,Q4) ac-cording to quartiles of basophils percentage at baseline. Cox regression models were used to identify the association be-tween basophils percentage and CKD. Results The cohort consisted of 17 173 subjects, including 10 614 males and 6 559 females. There were 737 CKD cases occurring during the 42 204.04 person-years following up,resulting in an in-cidence of 17.46/1 000 person-year. The multivariate Cox regression model with adjusting age and gender showed that HRs (95%CI) of basophils percentage to CKD for the groups of Q2, Q3 and Q4 (with Q1 as reference group) were 0.990(0.776-1.263),1.235(1.011-1.509) and 1.352(1.099-1.663) respectively. Furthermore, after all other related variables such as body mass index,hypertension,diabetes,blood uric acid,serum creatinine,blood urea nitrogen,to-tal cholesterol,low density lipoprotein cholesterol and triglyceride were adjusted,the HRs(95%CI) of Q2,Q3 and Q4 were 0.966(0.740-1.262),1.225(0.985-1.525) and 1.355(1.077-1.705), respectively. Conclusion Increasing ba-sophils percentage is an independent risk factor of CKD.