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曾经认为,开裂青霉素和先锋霉素Ⅱ的β-内酰胺的β-内酰胺酶,要革兰氏阳性菌和革兰氏阴性菌对该类药物的主要耐药机制。从临床分离的耐氨苄青霉素的大肠杆菌
It has been thought that the β-lactamase that breaks down the penicillin and the β-lactam of cephalosporin II is the major mechanism of resistance to these drugs by Gram-positive bacteria and Gram-negative bacteria. Ampicillin-resistant Escherichia coli isolated from clinical practice