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目的 评价介入性热化疗对兔肝癌的抑瘤效果。方法 将VX 2瘤细胞接种于 6 0只新西兰白兔肝右叶 ,建立兔肝癌模型 ,随机分 4组 ,每组 15只。利用导管经肝动脉分别给生理盐水、37℃盐水 +阿霉素、6 0℃热生理盐水及ADM溶液 (6 0℃ )于不同组 ,1周后后观察各组肿瘤体积及血清AST水平 ,观察荷瘤兔的存活期。结果 ADM溶液 (6 0℃ )热灌注组生长率 (0 .5 3± 0 .2 1)与对照组 (3.4 8± 1.17)相比有显著性差异 (P <0 .0 1) ,与栓塞组 (1.13± 0 .2 3)、ADM溶液 (37℃ )灌注组 (1.0 9± 0 .2 6 ) )相比亦有显著性差异 (P<0 .0 5 )。ADM溶液 (6 0℃ )热灌注组存活期 (5 0 .0± 2 .0d)与对照组 (40 .5± 3.0d)相比差异有显著性 (P <0 .0 5 )。ADM溶液 (6 0℃ )热灌注组血清AST水平治疗前后变化与其它各组相比无显著性差异 (P >0 .0 5 ) ,与对照组相比有显著性差异 (P <0 .0 5 )。结论 ADM溶液 (6 0℃ )热灌注组可大大降低肿瘤生长率 ,延长存活期 ,对肝功的损害是可逆的 ,其抑瘤效果更强
Objective To evaluate the anti-tumor effect of interventional thermochemotherapy on rabbit liver cancer. Methods VX 2 tumor cells were inoculated into the right lobe of 60 New Zealand white rabbits to establish a model of rabbit liver cancer and were randomly divided into 4 groups of 15 rats each. Tumor volume and serum AST levels in each group were observed with saline, 37 ℃ saline + doxorubicin, 60 ℃ hot saline and ADM solution (60 ℃) Observe the survival of tumor-bearing rabbits. Results Compared with the control group (3.4 8 ± 1.17), the growth rate of ADM solution (60 ℃) in the heat perfusion group was significantly lower than that in the control group (P0.51 ± 0.21) (1.13 ± 0.23), ADM solution (37 ℃) perfusion group (1.09 ± 0.26)) (P <0.05). There was a significant difference (P <0.05) between the ADM group (60 ℃) and the control group (40.5 ± 3.0d). There was no significant difference between before and after treatment in AST group (P> 0.05), but there was significant difference between the two groups (P <0. 0 5) 5). CONCLUSION: Thermal perfusion with ADM solution (60 ℃) can significantly reduce the tumor growth rate, prolong the survival period and impair the liver function. The anti-tumor effect is stronger