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[目的]探讨血清摄食抑制因子nesfatin-1在稳定期慢性阻塞性肺疾病(COPD)患者中的表达水平及其临床意义.[方法]选取稳定期COPD患者(COPD组)和健康志愿者(健康对照组)各100例.检测并对比两组血清nesfatin-1水平、营养指标[血红蛋白(Hb)、血清白蛋白(ALB)]和肺功能[第1秒用力呼气容积占预计值百分比(FEV1 ％)及FEV1占用力肺活量的比率(FEV1/FVC)],分析稳定期COPD患者血清nesfa- tin-1水平与营养指标和肺功能指标的相关性.[结果]COPD组血清nesfatin-1水平高于健康对照组,Hb、 ALB、FEV1％、FEV1/FVC均明显低于健康对照组,其差异均有统计学意义(P <0.05) ; COPD组患者血清 nesfatin-1 水平与 Hb、ALB、FEV1 ％、FEV1/FVC 均呈明显负相关性(r = - 0. 608、- 0. 522、- 0.529、 -0.478,P <0.05) .[结论]血清nesfatin-1水平可能是COPD患者营养评估及肺功能分级潜在的生物标记物.“,”[Objective]To detect the serum level of nesfatin-1 in patients with stable chronic obstructive pulmonary disease (COPD) and explore its relationship with nutritional indicators and lung function.[Meth- ods]A total of 100 patients with stable COPD and 100 healthy volunteers were selected as COPD group and healthy control group,respectively. Serum nesfatin-1 levels were detected by enzyme-linked immunosorbent assay (ELISA),and the nutritional indicators and lung function were detected and compared as well. The nutritional indicators included hemoglobin (Hb) and serum albumin (ALB). The lung function index included percentage of forced expiratory volume in the first second (FEV1),FEV1/FVC. Pearson correlation analysis was used to determine the correlation between serum nesfatin-1 level and nutritional status and lung function in patients with stable COPD.[Results]The serum nesfatin-1 level in the COPD group was higher than that in the healthy control group. The Hb,ALB nutritional, FEV1 and FEV1/FVC were significantly lower the healthy group. The differences were statistically significant (P <0.05). The serum nesfatin-1 levels were negatively correlated with Hb,ALB, FEV1,and FEV1/FVC in the COPD group ( r =- 0.608,-0.522, -0.529,-0,478, P <0.05).[Conclusion]Serum nesfatin-1 levels may be a potential biomarker for nutritional assessment and pulmonary function grading in patients with COPD.