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作为G蛋白偶联受体超家族的重要成员，CXC趋化因子受体1(CXCR1)是CXC趋化因子白细胞介素-8最重要且颇具亲和力的受体之一。CXCR1常表达于中性粒细胞、单核细胞、T细胞等细胞表面，并且可与CXC趋化因子配体(CXCL)6、CXCL7、CXCL8相结合。研究发现CXCR1在促进恶性肿瘤转移、化疗耐药以及维持肿瘤干细胞特性中发挥至关重要的作用，下调CXCR1表达能显著抑制恶性肿瘤的生物学特性。目前学术界将CXCR1视为恶性肿瘤的原癌基因，CXCR1有望成为恶性肿瘤诊断和治疗的潜在靶点。“,”As an important member of the G protein coupled receptor superfamily, CXC chemokine receptor 1 (CXCR1) is also one of the most important and affinity receptors for CXC chemokine interleukin 8. CXCR1 is often expressed on the surface of cells such as neutrophils, monocytes and T cells, which can bind to CXC chemokine ligand (CXCL)6, CXCL7 and CXCL8. Studies have found that CXCR1 plays a vital role in promoting the metastasis, chemotherapy resistance and maintaining the characteristics of tumor stem cells. Down-regulating the expression of CXCR1 can significantly inhibit the biological characteristics of malignant tumors. At present, the academic field regards CXCR1 as the proto-oncogene of malignant tumors. CXCR1 is expected to become a potential target for the diagnosis and treatment of malignant tumors.