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目的:观察大剂量甘草酸二铵治疗以顽固性转氨酶异常为主的慢性肝炎的疗效。方法:80例慢性肝炎病人随机分成二组,在基础治疗之上对照组应用甘草酸二铵250mg/d,治疗组应用甘草酸二铵500mg/d,疗程4周。结果:治疗后对二组患者的谷丙转氨酶水平和复常率恢复情况进行比较,治疗组的谷丙转氨酶较对照组有明显下降,差异有显著意义(t=7.98,P<0.001)。复常率也显著高于对照组(X2=16.97,P<0.001)。结论:大剂量甘草酸二铵对以顽固性转氨酶异常为主的慢性肝炎有较好的疗效。
Objective: To observe the effect of high-dose diammonium glycyrrhizinate on chronic hepatitis with refractory aminotransferase abnormalities. Methods: Eighty patients with chronic hepatitis were randomly divided into two groups. The control group received 250mg / d of glycyrrhizic acid on the basis of the basic treatment. The treatment group received diammonium glycyrrhizinate 500mg / d for 4 weeks. Results: Compared with the control group, the alanine aminotransferase level and recovery rate of normal group were significantly decreased in the two groups after treatment (t = 7.98, P <0.001). The normalization rate was also significantly higher than the control group (X2 = 16.97, P <0.001). Conclusion: High-dose diammonium glycyrrhizinate has a good effect on chronic hepatitis with refractory transaminase abnormality.