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在非洲,结核是与人类免疫缺陷病毒(HIV)感染有关的常见严重疾病之一。对卢旺达和其他结核病高发国家中的婴儿,世界卫生组织(WHO)建议在出生时接种卡介苗(BCG)。本文报道了在基加利(卢旺达首都)进行研究的总结,该项研究观察了血 HIV 阳性和阴性母亲所生婴儿,接种卡介苗后免疫反应和副作用的发生情况。那里育龄妇女艾滋病病毒感染率高达30%。1988年11月,在基加利开始了一项关于母亲 HIV-1传播给婴儿的前瞻性研究。截止1989年6月,该项研究登记了422名出生后第一周内注射了冻干 BCG 的新生儿(皮内注射
In Africa, tuberculosis is one of the most common and serious diseases associated with human immunodeficiency virus (HIV) infection. For infants in Rwanda and other high-TB countries, the World Health Organization (WHO) recommends BCG vaccination at birth. This article reports a summary of the study carried out in Kigali, the capital of Rwanda, which looked at the immunization and side effects of vaccination of BCG in infants born to HIV-positive and -negative mothers. Where women of reproductive age have HIV prevalence rates as high as 30%. In November 1988, a prospective study was started in Kigali on the transmission of HIV-1 to mothers. As of June 1989, the study enrolled 422 newborns injected with lyophilized BCG in the first week after birth (intradermal injection