目的　探讨人胎舌内氮能神经元的发育。　方法　用NADPH d组织化学法对人胎舌内氮能神经元的分化、迁移和生长发育进行观察。　结果　第 4个月胎龄时 ,舌上皮组织中层圆形细胞分化形成梭形的氮能神经细胞 ,并从上皮组织向上皮下层和肌组织迁移。神经细胞体较小 ,NOS阳性反应较弱 ,其生长发育过程可分为两个时期 ,从第 4～ 7个月龄末为生长发育期 ,神经元胞体由小逐渐增大 ,数目增加 ,NOS阳性反应逐渐增强。至第 7个月龄时 ,处于生长发育的高峰。其形态特征 :由梭形发育成蝌蚪形 ,之后形成多样性形态。第 8～ 10个月龄为成熟期 ,表现为氮能神经元胞体较大 ,NOS呈强阳性反应。在上皮下层和肌组织内氮能神经元呈散在分布 ,有的部位聚集成明显的舌内神经节。　结论　舌内氮能神经元来源于胚胎早期舌的上皮组织 ,通过分化、迁移、增殖和生长发育形成氮能神经元 Objective To investigate the development of Nerve Nerve Neurons in human tongue. Methods NADPH d histochemical method was used to observe the differentiation, migration, growth and development of NAC in human tongue. Results At the fourth month of gestation, the middle circular epithelial cells differentiated to form spindle-shaped N-type nerve cells and migrated from the epithelium to the subepithelium and muscle. Nerve cell body is small, NOS-positive reaction is weak, the growth and development process can be divided into two periods, from the first 4 to 7 months of age for the growth and development, neuronal cell body gradually increased from small to small, the number increased, NOS Positive reaction gradually increased. To the seventh month of age, the growth and development of the peak. Its morphological characteristics: the spindle shape developed into a tadpole, after forming a diversity of forms. The 8th to 10th months of age were mature, which showed that the NOS positive neurons were large and NOS was strongly positive. In the subepithelium and muscle tissue nitrogen energy neurons scattered distribution, and some sites gathered into the obvious tongue of the ganglion. Conclusions Nitric oxide neurons in tongue originate from the epithelial tissues of tongue in the early embryo and form nitrogen-capable neurons through differentiation, migration, proliferation and growth