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人类 HLA-DR 抗原(相当于小鼠 H-2Ⅰ区的 Ia 抗原)也可称为免疫相关抗原,Ia-like,在移植免疫上参与细胞识别和调节,激发 T 细胞增殖及同种异型抗体的产生。在组织移植配型中,目前都认为 DR 抗原的重要性大于 HLA-ABC 抗原。如有一个或两个抗原相配合,能显著提高移植物的存活率。因此,对 DR 分型,已为国际医学界所重视。1977年在英国召开的第七届国际组织相容性专题讨论会上(以下简称七届会议)以及1980年在美国召开的八届会议上,HLA-DR 分型都列为主要议题。现在所知,HLA 遗传区域的一系列紧密连锁的基因都属于人体主要组织相容性复合体
The human HLA-DR antigen (equivalent to the Ia antigen in the H-21 region of the mouse) may also be referred to as an immunologically relevant antigen, Ia-like, which is involved in cell recognition and regulation on transplantation immunity, stimulates T cell proliferation and alloantibody produce. Tissue transplantation in the distribution, the current view that the importance of DR antigen than HLA-ABC antigen. If one or two antigens in cooperation, can significantly improve graft survival. Therefore, the classification of DR has been valued by the international medical community. HLA-DR typing was the main topic at the Seventh Symposium of International Organizational Symposia held in England in 1977 (hereinafter referred to as the Seventh Session) and the eight sessions held in the United States in 1980. It is now known that a series of closely linked genes in the HLA genetic region belong to the major histocompatibility complex